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Antihistamines are dosed for the nose and the amount of histamine released in a hives outbreak can be much larger than that released in a sneezing attack.If one cetirizine or fexofenadine hasn’t worked in an hour, take a second one.Inhalation sedation is also sometimes referred to as relative analgesia.

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Typically, levels are (i) agitation, (ii) calm, (iii) responsive to voice alone, (iv) responsive to tactile stimulation, (v) responsive to painful stimulation only, and (vi) unresponsive to painful stimulation.

I also frequently see patients for evaluation of hives when their rash is something altogether different.